Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

Table 1 Summary of clinical signs and PEDV shedding of Gn piglets after PEDV inoculation (1–21 dpi)

Group	No. of pigs	Mortality rate	Diarrhea rate	Onset of diarrhea (dpi)	Peak mean RNA shedding titer (log₁₀ copies/mL)	Onset of peak RNA shedding (dpi)
icPC22A	6 a	100% (5/5) b	100% (5/5) b	1.20 ± 0.40 b	12.12 ± 0.53 b	1.20 ± 0.40
E191A-P1	4 a	0 (0/3) c	66.7% (2/3) c	6.00 ± 0.00 c	5.06 ± 0.11 c	6.67 ± 5.25
Mock	6 a	0 (0/5)	0 (0/5)	NA	NA	NA

^aOne pig from each group were euthanized at 3 dpi for histopathological examination and were excluded for the calculation of Mortality and Diarrhea rates, Peak mean RNA shedding and Onset of peak RNA shedding
dpi days post-inoculation
Fecal scores of 2 and 3 were considered as moderate diarrhea and severe diarrhea, respectively
^b,cDifferent letters denote significant difference between groups (p < 0.05)
NA not available

ISSN: 2045-3701