Fig. 4
Induction of partial protection by E191A-P1 mutant in Gn pigs against icPC22A challenge. a Fecal consistency scores of pigs post challenge. Fecal consistency was scored as follows: 0, solid; 1, pasty; 2, semiliquid; and 3, liquid. Scores of ≥ 2 and 3 were considered diarrhea and severe diarrhea, respectively. Each dot represents the score of an individual pig; each line indicates the mean scores of a group. A pig with a score of ≥ 2 was defined as having diarrhea and a score of 3 was severe diarrhea. b Fecal PEDV RNA shedding profile of pigs post challenge. Each line indicates the mean values of a group. The dash line at 4.8 log10 copies/mL indicates the detection limit. c Survival curves of pigs by 9 dpc. d VN antibody titers in serum samples collected at different time points