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Fig. 6 | Cell & Bioscience

Fig. 6

From: Blocking the interaction between interleukin-17A and endoplasmic reticulum stress in macrophage attenuates retinal neovascularization in oxygen-induced retinopathy

Fig. 6

Inhibition of ER stress or IL-17A alleviated RNV. a Immunofluorescence staining of fluorescein-conjugated lectin in retinal flat-mounts of normal and OIR WT mice at P17 treated with 4-PBA or IL-17ANab or vehicle, as well as in retinal flat-mounts of normal and OIR IL-17A KO mice. Areas of vaso-obliteration (within yellow lines) and NV (red) were quantified. b, c Quantification of the avascular area (b) and NV area (c) of retinal flat mounts. N = 6 per group. ns, no significance. ***P < 0.001 compared with OIR (WT)-vehicle group. ###P < 0.001 compared with OIR (WT)-control group. Scale bars, 500 μm. Data are shown as mean ± SEM. ns, no significance

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