Table 2 Experimental studies on the concentration and role of Gal-3 in AD
From: Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
Animal models | Main findings | Authors |
|---|---|---|
5xFAD mice and Gal-3 knockout mice | Gal-3 acted as an endogenous TREM2 ligand to modulate the proinflammatory response in AD | Boza-Serrano et al. [12] |
Aβ25-35-induced Wistar rats | Neuroinflammation induced by the Aβ25-35 increased the expression of Gal-3 in astrocytes and microglia and damaged spatial memory | RamÃrez et al. [92] |
Gal-3 knockout mice and APP/PS1 mice | Overexpression of Gal-3 enhanced Aβ oligomerization through direct interactions with Aβ and inhibition of the degradation of Aβ | Tao et al. [90] |