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Table 3 Hub genes with degree ≥ 10 in DEGs between adult SR and P0 SR

From: Neuromuscular junction-specific genes screening by deep RNA-seq analysis

Gene

Full name

Function

Zbtb16

Zinc finger and BTB domain containing 16

DNA-binding transcription repressor activity, RNA polymerase II-specific

Ubc

SUMO-conjugating enzyme UBC9

Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase

Asb14

Ankyrin repeat and SOCS box protein 14

May be a substrate-recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Fbxo44

F-box only protein 44

Substrate-recognition component of the SCF -type E3 ubiquitin ligase complex

Asb11

Ankyrin repeat and SOCS box protein 11

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Asb2

Ankyrin repeat and SOCS box protein 2

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Klhl21

Kelch-like protein 21

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis

Fbxo44

F-box only protein 44

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex

Asb10

Ankyrin repeat and SOCS box protein 10

May be a substrate-recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Asb15

Ankyrin repeat and SOCS box protein 15

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Trim63

E3 ubiquitin-protein ligase TRIM63

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids

Fbxo32

F-box only protein 32

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins