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Table 3 Hub genes with degree ≥ 10 in DEGs between adult SR and P0 SR

From: Neuromuscular junction-specific genes screening by deep RNA-seq analysis

Gene Full name Function
Zbtb16 Zinc finger and BTB domain containing 16 DNA-binding transcription repressor activity, RNA polymerase II-specific
Ubc SUMO-conjugating enzyme UBC9 Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase
Asb14 Ankyrin repeat and SOCS box protein 14 May be a substrate-recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Fbxo44 F-box only protein 44 Substrate-recognition component of the SCF -type E3 ubiquitin ligase complex
Asb11 Ankyrin repeat and SOCS box protein 11 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Asb2 Ankyrin repeat and SOCS box protein 2 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Klhl21 Kelch-like protein 21 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis
Fbxo44 F-box only protein 44 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex
Asb10 Ankyrin repeat and SOCS box protein 10 May be a substrate-recognition component of a SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Asb15 Ankyrin repeat and SOCS box protein 15 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
Trim63 E3 ubiquitin-protein ligase TRIM63 E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids
Fbxo32 F-box only protein 32 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins