Table 2 Hub genes with degree ≥ 10 in DEGs between adult SR and NSR

Mag

Guanylate-binding protein 1

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus (By similarity). Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes

Ugt8a

2-Hydroxyacylsphingosine 1-beta-galactosyltransferase

Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system

Plp1

Myelin proteolipid protein

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin

Kcna1

Potassium voltage-gated channel subfamily A member 1

Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability

Sox10

Transcription factor SOX-10

Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination

Fa2h

Fatty acid 2-hydroxylase

Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis