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Table 1 Domain structure function relationship

From: Physiological relevance of post-translational regulation of the spindle assembly checkpoint protein BubR1

Domain

Function

KEN1

APC/C degron; Binds Cdc20

MCC assembly: Brings together BubR1, Bub3, Mad2, Cdc20

TPR motifs

Binds KNL1 protein (MELT motifs) on kinetochores

Anaphase inhibition: Binds an E2 binding domain on APC/C

D box 1

APC/C degron; Binds Cdc20 at its D box recognition domain, preventing recognition of D box-containing substrates

ABBA motif (A1)

Binds Cdc20

KEN2

APC/C degron; Binds Cdc20

APC/C inhibition: Blocks substrate recruitment to APC/C

ABBA motif (A2)

Binds Cdc20

GLEBS;

Bub3-binding

BubR1 recruitment to kinetochores via Bub3 binding

ABBA motif (A3)

(Phe box; IC20BD)

Binds Cdc20-APC/C

Unknown the extent of its importance

D box 2

APC/C degron; Binds Cdc20 at its D box recognition domain, preventing recognition of D box-containing substrates

KARD

PP2A-B56 recruitment to kinetochores

Kinase domain

Potentially catalytic: autophosphorylation, targeted phosphorylation of other mitotic proteins

May be involved in BubR1 protein stability