Fig. 1

Domain organization of BubR1. The main functions associated with the various domains are highlighted. Domains regulating BubR1 degradation include KEN-Boxes (KEN1 and KEN2), Destruction Boxes (D1 and D2), and ABBA (named for found in Cyclin A, BubR1, Bub1, and AMC1) domains. Domains responsible for protein–protein interactions include tetratricopeptide repeat motif (TPR), Gle2-binding-sequence (GLEBS), and kinetochore attachment regulatory domain (KARD). The C-terminal region of BubR1 contains the putative kinase domain. Shown are characterized and experimentally observed PTMs (above) and location of mutations found in BubR1 relating to cancer, PCS, and MVA (below). PTMs highlighted in yellow have been experimentally studied and are discussed in this review