Fig. 2

Host proteome upon HBV integration. a Summary of identified and quantified proteins and peptides. b Pearson’s correlation (R) plots for three representative experiments from HepG2.2.15 cells. c Venn diagrams of peptides in HepG2.2.15 Peptide numbers are indicated. d The subcellular location of differentially expressed proteins. e Distribution of regulated proteins quantification results. f, g L/H ratios for selected regulated proteins from three biological replicates in HepG2.2.15 cells. h The levels of the secreted HBeAg and HBsAg were determined by ELISA from the cell culture supernatants samples co-transfected (1:1) with pHBV1.3 and indicated plasmids. The data represent the average of three independent experiments and were analyzed with a two-tailed unpaired t test. Graphs indicate mean ± S.D. (n = 3) derived from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. i L/H ratios for selected regulated proteins from three biological replicates in HepG2.2.15 cells. j KEGG pathway analysis