Fig. 7From: Tissue-specific role and associated downstream signaling pathways of adiponectinRole of adiponectin in bone marrow-derived stem cells. Adiponectin increases osteoblast differentiation through AdipoR1-AMPK-P38-NF-ĸB signaling pathway-mediated expression and activation of COX-2. Adiponectin-induced activation of P38 also contributes to osteoblast differentiation through the activation of JNK. Adiponectin signaling increases osteogenesis through the activation of Wnt/β-cat-mediated expression of osteogenic genes including OCN, BMP-2, RUNX2 and ALP. Adiponectin-induced activation of AdipoR1-CK2-SMAD1/5/8 upregulates the transcription and activation of SDF-1 and subsequently increases the migration and recruitment of BMSCsBack to article page