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Fig. 9 | Cell & Bioscience

Fig. 9

From: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

Fig. 9

RRM2 silencing collaborates with radiotherapy to enhance anti-tumor effects and activation of cGAS/STING pathway. a The synergistic effects of siRRM2 and radiotherapy on apoptosis using flow cytometry in A549 and PC9 cells. b The statistical analyses on apoptosis rates. c The synergistic effects of siRRM2 and radiotherapy on A549 and PC9 cell colony formation. d The statistical analyses on colony formation. e Immunoblotting of cGAS/STING pathway-related proteins after siRRM2 treatment and radiotherapy in A549 and PC9 cells. f The synergistic effects of siRRM2 and radiotherapy on the mRNA levels of IFNβ, CCL5 and CXCL10 in A549 and PC9 cells. All tests were repeated 3 times. *p < 0.05, **p < 0.01, ***p < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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