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Fig. 8 | Cell & Bioscience

Fig. 8

From: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

Fig. 8

RRM2 silencing has anti-tumor effects and enhances CD8 + T cells infiltrations in Lewis mice model. Lewis mice were injected with LV-NC and LV-siRRM2 infected LLC cells. a The tumor volumes were measured every 3 days and depicted in the line chart. b, c Representative IVIS spectrum imaging for tumor-bearing mice. The fluorescence radiance comparison between LLC-LV-NC and LLC-LV-siRRM2 groups. d, e Representative flow cytometry of CD4 + and CD8 + T cells in spleens and tumors. Quantitative analysis of CD4 + and CD8 + T cells in spleens and tumors. f, g Representative image of CD4 and CD8 staining for spleens and tumors by IHC. Scale bar: 100 μm. *p < 0.05, **p < 0.01, ns: not significant

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Cell & Bioscience

ISSN: 2045-3701

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