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Fig. 6 | Cell & Bioscience

Fig. 6

From: RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma

Fig. 6

STING downregulation partially rescued the activation of cGAS/STING signaling pathway induced by RRM2 silencing. The mRNA levels of RRM2 in A549 (a) and PC9 (b) cells after transfecting siRRM2, siSTING or their combination. The mRNA levels of STING in A549 (c) and PC9 (d) cells after transfecting siRRM2, siSTING or their combination. (e) The effects of siRRM2, siSTING or their combination on cGAS/STING pathway were evaluated by immunoblotting. The mRNA levels (f) and the secretion (g) of IFNβ, CCL5 and CXCL10 in A549 and PC9 cells after transfecting siRRM2, siSTING or their combination. All tests were repeated 3 times. **p < 0.01, ***p < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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