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Fig. 7 | Cell & Bioscience

Fig. 7

From: KLF7/VPS35 axis contributes to hepatocellular carcinoma progression through CCDC85C-activated β-catenin pathway

Fig. 7

VPS35 interacts with Ccdc85c to participate in HCC progression. a Mass spectrometry analysis of VPS35-interacted proteins after co-IP. b Western blot was performed to confirm co-IP results. c The expression level of Ccdc85c in HCC patients and normal tissues by analyzed TCGA data. d The overall survival of HCC patients using KM-plotter by TCGA database analysis. e The disease-free survival of HCC patients predicted using KM-plotter. f Western blot determined Ccdc85c expression following siRNA or VPS35 overexpression. g CCK-8 assay was performed to examine cell viability following alteration of Ccdc85c and VPS35 expression in HCC cells. h colony formation and statistical data was performed to examine cell proliferation following alteration of Ccdc85c and VPS35 expression in HCC cells. i Statistical analysis of colony formation assay results. j Transwell assay was performed to examine cell invasion following alteration of Ccdc85c and VPS35 expression in HCC cells. k Statistical analysis of transwell assay results. **p < 0.01, ***P < 0.001

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