Fig. 7

Knockout of EIF5A2 using lentiviral CRISPR/Cas9 nickase vector suppressed primary ovarian tumor growth in an orthotopic ovarian mouse model. a Primary ovarian tumors at one month following intrabursal injection of EIF5A2 KO and control SKOV3 cells (n = 5). b Western blot and densitometry analysis of EIF5A2, p-Smad2 and EMT markers from primary tumor of mice xenografted with EIF5A2 KO and control cells C. Sections of primary ovarian tumors were stained with H&E. (*p < 0.05, **p < 0.01, ***p < 0.001)