The role of CPEB family proteins in the nervous system function in the norm and pathology

Cell & Bioscience

Table 1 Nervous system disorders in which the CPEB proteins may be used as targets for gene therapy

Disease	CPEB protein	CPEB expression in disease	Participation of CPEB in the pathogenesis or correction of the disease	References
Autism spectrum disorder	CPEB4	Decreased level of the protein, but not of the mRNA	Mis-splicing of CPEB4 mRNA leads to deregulated expression of CPEB4 target genes involved in ASD	[63]
Gliomas	CPEB1	Decreased expression	Increased CPEB1 expression reduces proliferation and self-renewal of tumor cells	[64, 65]
Gliomas	CPEB4	Increased expression	Decreased CPEB4 expression leads to reduction in tumor size, cell proliferation rate, microvessel density, and tumor cell invasion and migration	[66,67,68]
Fragile X syndrome	CPEB1	Expression is normal	Deletion of the CPEB1 gene in mice suppresses pathological processes associated with the syndrome	[73, 74]
Huntington's disease	CPEB1–4	Decreased level of the protein in the cytoplasm	Increased expression of CPEB proteins reduces the pathogenicity of protein aggregates in Drosophila	[80]

ISSN: 2045-3701