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Fig. 5 | Cell & Bioscience

Fig. 5

From: Glioblastoma stem cell (GSC)-derived PD-L1-containing exosomes activates AMPK/ULK1 pathway mediated autophagy to increase temozolomide-resistance in glioblastoma

Fig. 5

PD-L1-ex triggered autophagy in TMZ treated TS-GBM cells by activating AMPK/ULK1 signaling pathway. a–c By conducting Western Blot analysis, the expression levels of phosphorylated AMPK (p-AMPK) and ULK1 (p-ULK1) were determined, and the results showed that PD-L1-ex activated AMPK/ULK1 pathway in TMZ-treated TS-GBM cells. d–f Autophagy associated biomarkers were examined, and the results showed that blockage of AMPK/ULK1 pathway abrogated the promoting effects of PD-L1-ex on autophagy in TMZ-treated TS-GBM cells. (Note: “Con” indicated “Control”, “T” suggested “TMZ”, “P” represented “PD-L1-ex”, “S” suggested “SBI-0206965”, and “C” represented “compound C”). Each experiment had at least 3 repetitions, and *P < 0.05

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Cell & Bioscience

ISSN: 2045-3701

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