Fig. 7From: Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axisSchematic of the signaling pathways involved in LPS-mediated astrocyte activation. Exposure of LPS leads to σ-1R-mediated activation of MAPKs signaling pathways, JNK/MAPK and p38/MAPK pathways, results in the subsequent activation of downstream FOXJ2 transcription factor, thus enhances HECTD1 expression and subsequently induces astrocyte activationBack to article page