Fig. 3
From: Involvement of HECTD1 in LPS-induced astrocyte activation via σ-1R-JNK/p38-FOXJ2 axis
Role of HECTD1 in astrocyte activation induced by LPS in vivo. a-c HECTD1 deletion reversed LPS-induced increased expression of GFAP in cortex (a), hippocampus (b), and striatum (c). d Densitometric analysis of (a), (b), and (c). HECTD1f/f mice or C57BL/6 J mice were infused with HBAAV2/9-GFAP-cre-T2A-EGFP into the lateral ventricle. Four weeks later animals were treated with LPS (i.p., 20 mg/kg) for 4 h and then sacrificed for western blot analysis. n = 4 animals for each group. **p < 0.01 and ***p < 0.001 vs. the Con + WT + GFAPcre group; ##p < 0.01 vs. the LPS + WT + GFAPcre group