Table 1 CRLs in regulation of mitochondrial functions

CRL1

Mdm30 (Yeast)

Fzo1

Inhibits Mitochondrial fusion

[46, 47]

Mdm34

Inhibits Mitochondrial fusion

[48]

Mfb1 (Yeast)

NR

Inhibits Mitochondrial fusion

[49]

β-TrCP1

MFN1

Inhibits Mitochondrial fusion

[35]

FBXW7

MIFT

Inhibits mitochondrial gene transcription and oxidative metabolism

[50]

SKP2

IDH1

Inhibits tricarboxylic acid (TCA) cycle

[51]

FBXL4

NR

Inhibits mitochondrial morphology, mtDNA integrity, and OXPHOS

[52,53,54, 56]

FBXL7

Survivin

Inhibits mitochondrial morphology and membrane potential

[55]

FBXO7

NR

Inhibits mitophagy

[59]

Decreases mitochondrial membrane potential, ATP production, and oxygen consumption, increases cytosolic ROS production

[58]

FBXO11

NR

Inhibits mitochondrial swelling

[57]

FBXO15

CLS1

Inhibits mitochondrial function

[60]

FBXO25

HAX-1

Induces apoptosis

[61]

CRL2

pVHL

HIF1α

Increases the rate of oxygen consumption

[64]

CRL3

Keap1

Nrf2

Promotes cellular oxidative stress and controls mitochondrial retrograde trafficking

[66, 67]

SPOP

INF2

Inhibits mitochondrial fission

[68]

CRL4A

CRBN

NR

Acts specifically as a Lon-type protease in mitochondria

[70]

BNIP3L

Inhibits mitophagy

[71]

DCAF6

NR

Maintain sarcomere structure and mitochondrial/ contractile function in cardiomyocytes

[72]

CRL4B

AhR

NR

Promotes mitochondrial biogenesis against oxidative damage

[74]

Suppresses mitochondrial dysfunction and apoptosis induced by cigarette smoke

[75]

CRL5

NR

TRAF6

Binds with SARM1 and recruited to PINK1 complexes on depolarized mitochondria and facilitates Parkin-induced mitophagy

[79]

NR

DEPTOR

Suppresses mitochondrial respiration, mtDNA copy number, and citrate synthase activity

[82]