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Fig. 4 | Cell & Bioscience

Fig. 4

From: Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Fig. 4

Host-interacting proteins of SARS-CoV-2 Orf6. a Cells transfected with either a control (mCherry (mCh)-FLAG) or Orf6-mCh-FLAG-expression vector were lysed. Conjugated-proteins were pulled-down using FLAG agarose beads. The pulled-down samples were analyzed by SDS-PAGE gel and visualized by silver stain (black arrowhead, mCh-FLAG; red arrowhead, Orf6-mCh-FLAG). b Graphic network display of the interactions between SARS-CoV-2 Orf6 and host proteins associated with “nuclear transport (GO:0051169)”. Interactions were identified by STRING, then proteins were clustered using Markov Cluster Algorithm and colored based on the result. Solid line, intra-cluster association; dashed line; inter-cluster association

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Cell & Bioscience

ISSN: 2045-3701

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