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Fig. 1 | Cell & Bioscience

Fig. 1

From: Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

Fig. 1

SARS-CoV-2 human protein–protein host interactome is conserved in Drosophila. a Schematic representation of SARS-CoV-2 genome. b Graphic display of the conservation of the SARS-CoV-2 and human host interactome in Drosophila. The graphs summarize the high-confidence interactions between SARS-CoV-2 proteins (bait, gray node) and human proteins (prey) described in Gordon et al. [10]. Human interacting proteins are colored based on their conservation score (i.e. DIOPT score [13]) for the best matching fly ortholog. c Bargraph summarizes the ortholog information displayed in (b). SARS-CoV-2 interacting human proteins that have fly orthologs defined or predicted by more than one source (i.e. DIOPT score >  = 2) have been included

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