Table 1 γδT cells activation: ligands and receptors
From: In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity
| Source | Ligand | Receptor | References |
|---|---|---|---|
| Bacterial | PAMP | TLR2/5 | [22] |
| IL-1 | IL-1R | [20] | |
| Lipid antigen-CD1d | Vδ1TCR | [25, 26] | |
| HMBPP-BTN3A1 | Vδ2TCR | [30, 92] | |
| Cancer cell | MICA/B, ULBP | NKG2D | [55, 57] |
| hMSH2 | NKG2D | [64] | |
| Nectin-like 5 | DNAM-1 | [54] | |
| B7-H6 | NKp30 | [59, 60] | |
| Not known | NKp46 | [58] | |
| F1-ATPase | Vδ2TCR | [61] | |
| annexin A2 | Vδ3TCR | [62] | |
| IPP-BTN3A1 | Vδ2TCR | [81, 84] |