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Table 1 γδT cells activation: ligands and receptors

From: In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity

Source

Ligand

Receptor

References

Bacterial

PAMP

TLR2/5

[22]

IL-1

IL-1R

[20]

Lipid antigen-CD1d

Vδ1TCR

[25, 26]

HMBPP-BTN3A1

Vδ2TCR

[30, 92]

Cancer cell

MICA/B, ULBP

NKG2D

[55, 57]

hMSH2

NKG2D

[64]

Nectin-like 5

DNAM-1

[54]

B7-H6

NKp30

[59, 60]

Not known

NKp46

[58]

F1-ATPase

Vδ2TCR

[61]

annexin A2

Vδ3TCR

[62]

IPP-BTN3A1

Vδ2TCR

[81, 84]

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Cell & Bioscience

ISSN: 2045-3701

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