TY - JOUR AU - Liang, Tao AU - Hang, Weijian AU - Chen, Jiehui AU - Wu, Yue AU - Wen, Bin AU - Xu, Kai AU - Ding, Bingbing AU - Chen, Juan PY - 2021 DA - 2021/03/06 TI - ApoE4 (Δ272–299) induces mitochondrial‐associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron JO - Cell & Bioscience SP - 50 VL - 11 IS - 1 AB - Apolipoprotein E4 (apoE4) is a major genetic risk factor of Alzheimer’s disease. Its C-terminal-truncated apoE4 (Δ272–299) has neurotoxicity by affecting mitochondrial respiratory function. However, the molecular mechanism(s) underlying the action of apoE4 (Δ272–299) in mitochondrial function remain poorly understood. SN - 2045-3701 UR - https://doi.org/10.1186/s13578-021-00563-y DO - 10.1186/s13578-021-00563-y ID - Liang2021 ER -