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Fig. 4 | Cell & Bioscience

Fig. 4

From: EGFL6 promotes colorectal cancer cell growth and mobility and the anti‐cancer property of anti-EGFL6 antibody

Fig. 4

EGFL6 activates EGFR and integrin signaling in CRC cells. a EGFL6-induced cell proliferation ability under SB273005 (an αvβ3 integrin inhibitor), and Erlotinib (a receptor tyrosine kinase inhibitor on EGFR (epidermal growth factor receptor) treatment in HCT116 cell line. b, c The migration, invasion and proliferation-associated protein signaling of HCT116 and HT29 after EGFL6 treatment by time and after silencing of EGFL6. d, e The mRNA expression of cell stemness maintenance associated gene, POU5F1 (POU class 5 homeobox 1), NANOG and LIN28 after EGFL6 silencing in HCT116 and HT29. *p < 0.05, **p < 0.01, ***p < 0.005

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Cell & Bioscience

ISSN: 2045-3701

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