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Fig. 8 | Cell & Bioscience

Fig. 8

From: The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation

Fig. 8

A schematic diagram illustrating the role of the YAP/HIF-1α/miR-182/EGR2 axis in asthma. The overexpression of YAP and HIF-1α promoted the expression of miR-182, thereby inhibiting EGR2 expression, increasing the expression of RORγt and IL-17A, and prompting the differentiation of CD4+T cells into Th17 cells, which ultimately aggravated asthma and lipid metabolism dysfunction

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