Fig. 1

Increased YAP, HIF-1α and miR-182 and decreased HDL-C level identified in asthma. a Th17 cell proportion in human PBMCs and mouse spleen cells detected by flow cytometry; b the serum level of IL-17A in asthma patients measured by ELISA; c RORγt mRNA expression in human PBMCs determined by RT-qPCR; d Western blot analysis of RORγt protein in human PBMCs; e mRNA expression of YAP and HIF-1α in human PBMCs determined by RT-qPCR; f Western blot analysis of YAP and HIF-1α proteins in human PBMCs; g miR-183/96/182 expression in human PBMCs determined by RT-qPCR. Comparisons between two groups were conducted by unpaired t test; * p < 0.05, compared with the normal individuals (normal); n = 22 in normal individuals; n = 29 in asthma patients. Each experiment was repeated 3 times independently