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Fig. 6 | Cell & Bioscience

Fig. 6

From: Identification of a potent antagonist of smoothened in hedgehog signaling

Fig. 6

0025A inhibits the accumulation of Smo on primary cilia. a Serum-starved Ptch−/− MEF cells were treated with DMSO, 10 μM GDC-0449 (GDC) and 10 μM 0025A for 24 h at 37 ℃. Then the cells stained with antibodies against Smoothened (Green) and ARL 13B (Red), a marker for primary cilia. b Percentage of Smo on primary cilia was quantitated (n = 100). Scale bar, 5 µm

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