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Fig. 3 | Cell & Bioscience

Fig. 3

From: Identification of a potent antagonist of smoothened in hedgehog signaling

Fig. 3

Identification of novel Smo inhibitors in U2OS cells. The U2OS cells stably overexpressing βarr2-GFP and Smo-633 were treated with DMSO (a), 1 μM cyclopamine (Cyc) (b), 100 nM 0025A (c), or 100 nM 0025A and 1 μM SAG (d) for 24 h at 37 ℃. The arrows showed the intravesicular aggregation of βarr2-GFP. e Percentage of the number of βarr2-GFP aggregation was quantitated. Scale bar, 10 µm

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