Fig. 4

The function of p53 centrosome localization and the effect of p53 on autophagy. Under oxidative stress, P53 accumulates in the centrosome and binds to 53BP1 to form a complex to stabilize the structure of the centrosome and ensure its normal function. Under strong external stimulation conditions, the P53-53BP1 complex dissociates and P53 nuclear translocation will be induced to stimulate autophagy to maintain centrosome homeostasis and prevent mitosis error and chromosome aberration