Skip to main content

Table 3 Univariate and multivariate analyses of the overall survival in 135 HCC cases

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Parameters Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
PRIM1 expression
High vs. low 3.271 2.080–5.146 < 0.001 2.042 1.248–3.343 0.005
Age (years)
 < 60 vs. ≥ 60 0.905 0.548–1.493 0.695    
Sex
 Male vs. female 0.920 0.517–1.636 0.777    
AFP level
 Positive vs. negative 1.722 1.012–2.932 0.043 1.564 0.912–2.648 0.104
Tumor size (cm)
 < 3 vs. ≥ 3 3.707 1.852–7.419 < 0.001 2.075 0.968–4.449 0.061
Edmondson-Steiner grade
 I + II vs. III + IV 2.404 1.158–4.990 0.015 1.643 0.766–3.522 0.202
Ascites
 Absent vs. present 2.530 1.620–3.951 < 0.001 2.377 1.497–3.773 < 0.001
TNM stage
 I + II vs. III + IV 2.697 1.701–4.275 < 0.001 1.712 1.023–2.862 0.041
  1. PRIM1 DNA primase subunit 1, TNM tumor-node-metastasis