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Table 3 Univariate and multivariate analyses of the overall survival in 135 HCC cases

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Parameters

Univariate analysis

Multivariate analysis

HR

95% CI

P

HR

95% CI

P

PRIM1 expression

High vs. low

3.271

2.080–5.146

< 0.001

2.042

1.248–3.343

0.005

Age (years)

 < 60 vs. ≥ 60

0.905

0.548–1.493

0.695

   

Sex

 Male vs. female

0.920

0.517–1.636

0.777

   

AFP level

 Positive vs. negative

1.722

1.012–2.932

0.043

1.564

0.912–2.648

0.104

Tumor size (cm)

 < 3 vs. ≥ 3

3.707

1.852–7.419

< 0.001

2.075

0.968–4.449

0.061

Edmondson-Steiner grade

 I + II vs. III + IV

2.404

1.158–4.990

0.015

1.643

0.766–3.522

0.202

Ascites

 Absent vs. present

2.530

1.620–3.951

< 0.001

2.377

1.497–3.773

< 0.001

TNM stage

 I + II vs. III + IV

2.697

1.701–4.275

< 0.001

1.712

1.023–2.862

0.041

  1. PRIM1 DNA primase subunit 1, TNM tumor-node-metastasis