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Fig. 8 | Cell & Bioscience

Fig. 8

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Fig. 8

PRIM1 enhanced tumor growth in xenograft model and 3D spheroid model. a The MHCC97H-derived xenograft tumors of NC group and Kd-PRIM1 group. b, c The volume and weight of MHCC97H-derived xenograft tumors in NC group and Kd-PRIM1 group. d The representative H&E staining of the xenograft tumors in each group. e The representative immunohistochemical staining (PRIM1, P53, UBE2C, Ki67, E-cadherin, N-cadherin, P-AKT, and P-mTOR) of the xenograft tumors. f The growth of the 3D spheroids derived from MHCC97H in each group in day 1–5. g The MHCC97H-derived spheroids in different group treated with sorafenib. **P < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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