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Fig. 6 | Cell & Bioscience

Fig. 6

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Fig. 6

PRIM1 downregulated P53 in a ubiquitination-dependent manner. a The enrichment plot of P53 signaling and ubiquitin mediated proteolysis in TCGA and ICGC datasets. b The expression of P53 signaling of HCC cells with PRIM1 knockdown or overexpression. c The expression of P53 expression in PRIM1-overexpressed HepG2 cells treated with boriezomib. d Expression of P53 in MHCC97H cells transfected with or without Kd-PRIM1 and treated with CHX (100 μM) for the indicated times. e Expression of P53 in HepG2 cells transfected with or without OE-PRIM1 and treated with CHX for the indicated times. f Ubiquitination of P53 in PRIM1-silenced MHCC97H cells. g Ubiquitination of P53 in PRIM1-overexpressed HepG2 cells

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