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Fig. 5 | Cell & Bioscience

Fig. 5

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Fig. 5

PRIM1 activated AKT/mTOR signaling of HCC cells. a Gene sets enrichment analysis (GSEA) of PRIM1 in TCGA LIHC dataset. b GSEA of PRIM1 in ICGC dataset. c The enrichment plot of PI3K/AKT/mTOR signaling and mTORC1 in TCGA LIHC dataset. d The enrichment plot of PI3K/AKT/mTOR signaling and mTORC1 in ICGC dataset. e, f The expression of PI3K/AKT/mTOR signaling markers was detected by western blotting, following PRIM1 knockdown or overexpression in HCC cells. g The expression of PI3K/AKT/mTOR signaling markers in PRIM1-overexpressed HepG2 cells treated with LY294002 or ink128. h The expression of EMT markers in PRIM1-overexpressed HepG2 cells treated with LY294002 or ink128. NES, normalized enrichment score

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Cell & Bioscience

ISSN: 2045-3701

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