Fig. 1

Areg expression in oral wound healing and skin fibrosis. a shows a summary of ontology analysis of transient up-regulated genes during oral mucosa wound healing. The list of genes with transient induction is shown in Additional file 1: Table S1. b shows a re-analysis of Areg expression during oral mucosa wound healing 8, and * indicates a significant change (p < 0.01). c shows re-analysis of Areg gene expression from GSE132869 (from Geo datasets), confirming the significant expression in bleomycin-induced skin fibrosis. Each dot represents one sample. PBS was used as a control, and BLM indicates bleomycin treatment. d shows time-dependent expression of Areg during bleomycin-induced skin fibrosis. Please note that Areg was consistently highly expressed in the skin biopsies after bleomycin treatment at different time points. *indicates a significant change (p < 0.01)