Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

Table 1 Effect of the related miRNAs on DNA methylation

miRNA	miRNA expression	Outcome	Disease	Refs.
miR-29 family	Down-expressed	Decrease targeting DNMT1, 3A, 3B and TET1	Multiple myeloma, lung cancer, Burkitt lymphoma, breast cancer, nasopharyngeal carcinoma	[79–81, 95, 97,98,99,100, 102]
miR-339 and miR-766	Down-expressed	Decrease targeting DNMT3B gene	Colorectal cancer	[11, 108, 107, 113,114,115, 122, 124, 183]
miR-221	Over-expressed	Increase directly targeting DNMT3b 3′UTR region	Breast cancer	[184]
miR-148b and miR-152	Down-expressed	decrease targeting DNMT-1 mRNA	Pancreatic cancer	[185]
miR-140	Down-expressed	Decrease directly targeting DNMT-1	Liver cancer	[90]
miR-140-5p		Decrease DNA methylation of STAT1 and Tbx genes CpG island	Autoimmune encephalomyelitis	[186]
miR-212	Down-expressed Down-expressed	Increase MeCP2 protein level	Gastric cancer	[187]
miR-373	Down-expressed	Increase MBD2 expression	Hilar cholangiocarcinoma	[188]
miR-638	Down-expressed	Increase MeCP2 mRNA level	Gastric cancer	[189]
miR-221/222	Down-expressed	Increase MBD2 expression	Cervical cancer	[190]
miR-19a/b	Down-expressed	Increase MeCP2 expression	Gastric cancer	[191]
miR-132	Over-expressed	Decrease MeCP2 expression	Chronic Cerebral Hypo perfusion	[192]

ISSN: 2045-3701