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Fig. 2 | Cell & Bioscience

Fig. 2

From: Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

Fig. 2

MiRNA and methylation: miRNA and DNA methylation have interaction with each other in two ways, including the effects of miRNA on methylation and vice versa. DNA methylation can affect 1) miRNA-related gene or 2) promoter region of miRNA processing enzymes and cofactors such as TRBP and DGCR8 and also can affect CPG sites of Drosha gene body. Mutually, a miRNA can affect DNA methylation in two ways, including 1) it can target genes of DNA methylation-related enzymes such as DNMTs, TETs, MECP2, and MBDs, and leads to hyper- or hypo-methylation of different genes. 2) Also, miRNA processing-related enzymes can directly or indirectly affect DNA methylation through recruiting DNMTs to CpG sites in the genome or at gene levels

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Cell & Bioscience

ISSN: 2045-3701

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