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Fig. 1 | Cell & Bioscience

Fig. 1

From: Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

Fig. 1

MiRNA properties. a IsomiRs as miRNA variants are categorized into three main types, including 3′ isomiR, 5′ isomiR, and polymorphic isomiR that they can affect a miRNA at the target level to select different mRNA (b) Arm selection is a feature of miRNA that can affect target selection of miRNA by isomiRs and it can occur in three common steps, including (d) 5p arms of a miRNA duplex selected as a guide strand to incorporates into the RISC complex., (e) 3p arms of a miRNA duplex may be selected as a guide strand to incorporates into the RISC complex., and (f) occasionally, two arms of a miRNA duplex can be used as guide RNA and incorporate into the RISC complexes with different target mRNAs. Note: the guide strand of a miRNA has weaker binding to Ago protein. However, the passenger strand has a tighter binding capacity to Ago protein. c Arm selection of a miRNA can be changed in different conditions that it termed as arm switching

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