Table 2 Comparison of Y haplogroups and SNV deletion pattern of AZFb-c amplicons of infertile men with “classical” and “non-classical” AZFb deletion
AZFb-c amplicon | Amplicon diagnostic SNV sites (A or B allele) | WALBAE BRA1 GI2 | AZG144 azoo-spermia | AZFG189 OAT | AZFG372 azoo-spermia | AZFG449 azoo-spermia | AZFG606 crytozoo-spermia | AZFG620 azoo-spermia | AZFG637 Azoo-spermia | AZFG712 OAT |
|---|---|---|---|---|---|---|---|---|---|---|
Testicular pathology | Meiotic arrest | Meiotic arrest | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | |
AZFb deletion type | Classical | Non-classical | Non-classical | Non-classical | Non-classical | Non-classical | Non-classical | Non-classical | Non-classical | |
Y haplogroups | R1B* | R1A1* | I1* | F* | R1A1A1 | R1A1A1 | I1* | R1A1A1 | C* | |
b2 | b2_AZFc-SFV B | − | − | − | − | − | − | − | − | − |
g1 | g1_AZFc-SFV B | − | − | − | − | − | − | − | − | + |
g1 | g1_BPY2-1_SNV | − | − | − | − | − | − | − | − | + |
r1 | DAZ-SNV_II A | − | − | + | − | − | − | + | − | + |
r2 | DAZ -SNV_III A | − | + | − | + | − | − | − | − | + |
r2 | DAZ-SNV_IV A | − | + | − | − | − | − | − | − | − |
gr1 | Gr_AZFc-SFV A | − | + | + | + | + | − | + | − | + |
b3 | b3_AZFc-SFV B | − | + | − | + | + | + | + | + | − |
yel1 | Goly_SNV_I B | + | − | + | − | + | + | + | + | − |
g2 | g2_AZFc-SFV B | + | − | + | − | + | + | + | + | + |