Anti-apoptotic effect of dapagliflozin (DAPA) on ischemia/reperfusion injured animals.
Representative images of TUNEL staining of the cardiac tissues (a) and quantification of the apoptotic areas (b) were shown. The plasma concentration of myocardial damage markers, lactate dehydrogenase (LDH) (c) and creatine kinase-MB (CK-MB) (d), in control animals and ischemia/reperfusion (I/R) animals with or without DAPA treatment were checked. The data were presented as the mean ± SD of eight animals in each group. (* indicating p < 0.05 compared with the control group; # indicating p < 0.05 compared to I/R without DAPA treatment)