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Table 2 Top 18 differential metabolites in the p53-wt vs. p53-KO HBE cells post 12.5 µg/mL silica

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Upregulated metabolites

Downregulated metabolites

Gene-ID

Fold change

Log2 (Fold)

VIP score

Gene-ID

Fold change

Log2 (Fold)

VIP score

Linoleic acid

91.30556568

6.5126309

1.522815

Oxoglutaric acid

0.054212046

 − 4.205242732

1.153971

Butyric acid

17.21165834

4.105314202

1.239433

Beta_Alanine

0.083038327

 − 3.590078819

1.266837

Alpha_Linolenic acid

16.48137866

4.042765023

1.529557

Fumaric acid

0.106235462

 − 3.234662673

1.066492

Stearic acid

13.95122891

3.802320304

1.432926

4_Hydroxyphenylpyruvic acid

0.138183866

 − 2.855338915

1.262136

Arachidonic acid

8.151991288

3.02715251

1.307153

l_Thyronine

0.160574413

 − 2.638686077

1.33295

Docosahexaenoic acid DHA

7.888603473

2.979769921

1.409017

Pyroglutamic acid

0.183156185

 − 2.448853673

1.0547

Valeric acid

6.513822845

2.703504484

1.326264

p_Hydroxyphenylacetic acid

0.18381705

 − 2.443657506

1.293357

Formic acid

5.821979245

2.541509696

1.244691

Hydroxyphenyllactic acid

0.188740975

 − 2.405520436

1.228796

11_cis_Eicosenoic acid

4.970626572

2.313427722

1.428579

3_Nitrotyrosine

0.214676537

 − 2.219763575

1.294143

Indoleacrylic acid

4.329224483

2.11410861

1.606161

Benzeneacetic acid

0.221848007

 − 2.1723565

1.111947

Pentadecanoic acid

3.848793752

1.944406363

1.180618

Hydroxypropionic acid

0.245830401

 − 2.024264755

1.654862

Palmitic acid

3.779422024

1.918165624

1.601808

Glyceric acid

0.258762543

 − 1.950299297

1.025171

N_Phenylacetylphenylalanine

3.737134456

1.90193247

1.476966

l_Alanine

0.259966065

 − 1.943604783

1.098831

3,4_Dihydroxyhydrocinnamic acid

3.660604188

1.872081787

1.231095

Cis and trans_Cinnamic acid

0.271785878

 − 1.879457598

1.155961

Docosapentaenoic acid 22n_6

2.176457553

1.121981884

1.026765

Phenylacetic acid

0.28363417

 − 1.817896749

1.418577

Isobutyric acid

1.771921197

0.825314444

1.012767

Nicotinic acid

0.284218303

 − 1.814928632

1.497762

Heptadecanoic acid

1.599045316

0.677210825

1.189061

N_Acetylserotonin

0.28649635

 − 1.803411334

1.53686

Docosapentaenoic acid DPA

1.480405616

0.565992513

1.072228

Suberic acid

0.303340107

 − 1.720991836

1.305605

  1. VIP: Variable important in projection, The larger the VIP, the greater the contribution of this variable to the grouping; Log2 (FC): the ratio of the average expression amount of metabolites in the two groups of samples. A positive value indicates up regulation and a negative value indicates down regulation