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Table 2 Top 18 differential metabolites in the p53-wt vs. p53-KO HBE cells post 12.5 µg/mL silica

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Upregulated metabolites Downregulated metabolites
Gene-ID Fold change Log2 (Fold) VIP score Gene-ID Fold change Log2 (Fold) VIP score
Linoleic acid 91.30556568 6.5126309 1.522815 Oxoglutaric acid 0.054212046  − 4.205242732 1.153971
Butyric acid 17.21165834 4.105314202 1.239433 Beta_Alanine 0.083038327  − 3.590078819 1.266837
Alpha_Linolenic acid 16.48137866 4.042765023 1.529557 Fumaric acid 0.106235462  − 3.234662673 1.066492
Stearic acid 13.95122891 3.802320304 1.432926 4_Hydroxyphenylpyruvic acid 0.138183866  − 2.855338915 1.262136
Arachidonic acid 8.151991288 3.02715251 1.307153 l_Thyronine 0.160574413  − 2.638686077 1.33295
Docosahexaenoic acid DHA 7.888603473 2.979769921 1.409017 Pyroglutamic acid 0.183156185  − 2.448853673 1.0547
Valeric acid 6.513822845 2.703504484 1.326264 p_Hydroxyphenylacetic acid 0.18381705  − 2.443657506 1.293357
Formic acid 5.821979245 2.541509696 1.244691 Hydroxyphenyllactic acid 0.188740975  − 2.405520436 1.228796
11_cis_Eicosenoic acid 4.970626572 2.313427722 1.428579 3_Nitrotyrosine 0.214676537  − 2.219763575 1.294143
Indoleacrylic acid 4.329224483 2.11410861 1.606161 Benzeneacetic acid 0.221848007  − 2.1723565 1.111947
Pentadecanoic acid 3.848793752 1.944406363 1.180618 Hydroxypropionic acid 0.245830401  − 2.024264755 1.654862
Palmitic acid 3.779422024 1.918165624 1.601808 Glyceric acid 0.258762543  − 1.950299297 1.025171
N_Phenylacetylphenylalanine 3.737134456 1.90193247 1.476966 l_Alanine 0.259966065  − 1.943604783 1.098831
3,4_Dihydroxyhydrocinnamic acid 3.660604188 1.872081787 1.231095 Cis and trans_Cinnamic acid 0.271785878  − 1.879457598 1.155961
Docosapentaenoic acid 22n_6 2.176457553 1.121981884 1.026765 Phenylacetic acid 0.28363417  − 1.817896749 1.418577
Isobutyric acid 1.771921197 0.825314444 1.012767 Nicotinic acid 0.284218303  − 1.814928632 1.497762
Heptadecanoic acid 1.599045316 0.677210825 1.189061 N_Acetylserotonin 0.28649635  − 1.803411334 1.53686
Docosapentaenoic acid DPA 1.480405616 0.565992513 1.072228 Suberic acid 0.303340107  − 1.720991836 1.305605
  1. VIP: Variable important in projection, The larger the VIP, the greater the contribution of this variable to the grouping; Log2 (FC): the ratio of the average expression amount of metabolites in the two groups of samples. A positive value indicates up regulation and a negative value indicates down regulation