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Fig. 5 | Cell & Bioscience

Fig. 5

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Fig. 5

Integrated transcriptomic and metabolomic analyses of p53-dependent metabolic pathways. a Details of the citrate cycle (TCA). Pink represents slightly upregulated metabolites or genes, green represents significantly downregulated metabolites or genes, blue represents insignificant changes. b Details of linoleic acid metabolism. Red represents significantly upregulated metabolites or genes, green represents significantly downregulated metabolites or genes, blue represents significant changes. c IL4I1, HPD, ALDH3A1, ACLY, ACO, ALOX15, CYP2J2, and CYP1A2 expression levels were determined using qRT-PCR in HBE cells of p53-wt, p53-wt treated with silica (p53-wt-SiO2), p53-KO, and p53-KO treated with silica (p53-KO-SiO2), respectively. Data are presented as means ± SD from three independent experiments; *p < 0.05 between different groups

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Cell & Bioscience

ISSN: 2045-3701

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