Fig. 4

Bioinformatic analysis of metabolomics. a A heatmap was used to visually represent upregulated and downregulated metabolites. b KEGG analysis illustrates the enrichment pathway for the significantly differential expressed metabolites. c Integrated transcriptomic and metabolomic analyses of p53-dependent metabolic pathways. d Details of phenylalanine metabolism. Pink represents slightly upregulated metabolites or genes, green represents significantly downregulated metabolites or genes, blue represents no significant changes