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Fig. 1 | Cell & Bioscience

Fig. 1

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Fig. 1

Significant differentially expressed genes between p53-wt and p53-KO cells post silica stimuli. HBE cells with or without p53 expression mediated by CRISPR/Cas9 knockout technology were divided into two groups, p53-wt and p53-KO. Cells were harvested at 24 h, followed by treatment with 12.5 µg/cm2 silica. A total of 52 genes were significantly altered, of which 31 genes were significantly upregulated in the p53-KO group compared with that of the p53-wt group post silica treatment (p < 0.05). Twenty-one genes were significantly downregulated in the p53-KO group compared with that of the p53-wt group post silica treatment (p < 0.05). b A heatmap illustrating the differentially expressed mRNAs in HBE cells with (p53-wt) or without CRISPR/Cas9-mediated p53-knockout (p53-wt) after silica exposure. Red represents upregulated and purple represents downregulated mRNAs. c A MA map illustrating the distribution of standardized genes. Red represents significant differentially expressed genes whereas blue represent genes with no significant changes in expression. d A volcano map illustrating the differentially expressed mRNAs in HBE cells with (p53-KO) or without CRISPR/Cas9-mediated p53-knockout (p53-wt) after silica. Red represents upregulated mRNA, green represents downregulated mRNA and blue represents the mRNA with no changes in expression

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