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Fig. 3 | Cell & Bioscience

Fig. 3

From: SOX4 maintains the stemness of cancer cells via transcriptionally enhancing HDAC1 revealed by comparative proteomics study

Fig. 3

Differentially expressed proteins in SOX4-overexpressing HCT-116 cells and pathway analysis. a The data from NanoLC-MS/MS analysis was subjected to quantitative analysis using stringent criteria. Unqualified data with the coefficient of variation more than 30 % between two technical replicates were excluded and the differentially expressed proteins were filtered with cutoff 1.5. In total, 215 differentially expressed proteins (128 upregulated, 87 downregulated) in SOX4-overexpressing HCT-116 cells were identified. OE: SOX4-overexpressing cells, C: Control cells with empty vector transfection. b The differentially expressed proteins in SOX4-overexpressing HCT-116 were subjected to iPathwayGuide online software for pathway enrichment and the results were listed. c SOX4 positively regulates the protein level of HDAC1 in colorectal cancer cells. The protein levels of HDAC1 in SOX4-overexpressing or SOX4-knockdown HCT-116 and HT-29 cells and their control cells identified by western blot

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