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Fig. 1 | Cell & Bioscience

Fig. 1

From: Neuregulin 1/ErbB4 signaling contributes to the anti-epileptic effects of the ketogenic diet

Fig. 1

Ketogenic diet (KD) treatment elevates threshold to seizure in KA-induced seizure model. a Diagrams of diet contents. b Experimental design. After 1 week of habituation, male adult mice were divided into two groups, fed with control diet (CD) or KD for 3 weeks. Ketone and glucose measurements were then performed. c Increased circulating levels of β-hydroxybutyrate after 3 weeks of KD treatment. n = 10 mice per group. Student’s t test, t(18) = 12.49, P < 0.0001. d Decreased circulating levels of glucose after 3 weeks of KD treatment. n = 10 mice per group. Student’s t test, t(18) = 6.604, P < 0.0001. e Experimental design of seizure induction with kainic acid (KA). One week after cannula implantation into the amygdala, mice were fed with CD or KD. At the end of 3-weeks, mice were infused with kainic acid (KA) through cannula and seizure behaviors were monitored. f KD treatment decelerated the development of seizures. Mice in two groups were subject to KA infusion and scored for seizure stage every 5 min. n = 10 mice for each group. Repeated two-way ANOVA, F(1,126) = 8.522, P = 0.0092. g The averaged seizure score was decreased in mice fed with KD. n = 10 mice for each group. Student’s t test, t(18) = 2.919, p = 0.0092

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