Fig. 7

Correlation between capability of neurosphere formation and tumor initiation of cells. a Culture of different cancer cells in serum-free medium for neurosphere formation. Cells cultured in their respective normal media served as a control. b Tumors formed in nude mice by injected cells. c, d Comparison of growth rate (c) and weight (d) of tumors derived from different cells. Significance of difference in tumor volume between two groups of mice was calculated using two-way ANOVA-Bonferroni/Dunn test, and significance of difference in tumor weight was calculated using two-tailed Student’s t-test. Data are shown as mean ± SEM. ****p < 0.0001