Table 1 Experimental studies that investigated the role of miRNAs involved in regulating apoptosis in endometriosis
From: Apoptotic functions of microRNAs in pathogenesis, diagnosis, and treatment of endometriosis
microRNA | Expression | Function | Application | References |
|---|---|---|---|---|
miR-33b | Down-regulated | Facilitating caspase 3 activity | Treatment and biomarker | [96] |
miR-191 | Up-regulated | Inhibition of TNF-alpha induced apoptosis and might contribute malignant transformation of endometriosis | Treatment and biomarker | [97] |
miR-503 | Down-regulated | Targeting BCL-2 mRNAs | Treatment and biomarker | [98] |
miR-183 | Down-regulated | Reducing apoptosis | Treatment and biomarker | [99] |
miR-29c | Down-regulated | Targeting c-JUN (a protein which regulates gene expression) | Treatment and biomarker | [100] |
miR-148a | – | Affecting BCL-2 expression and caspase-3/9 through G protein coupled estrogen receptor/miR148a/human leukocyte antigen G signaling pathway | Treatment | [101] |
miR-210 | Up-regulated | Inhibition of apoptosis by targeting signal transducer and activator of transcription 3 | Treatment and biomarker | [102] |
miR-196b | – | Affecting BCL-2 expression, activation of caspase-3 and caspase-7 | Treatment | [103] |
miR-363 | Down-regulated | Inducing apoptosis | Treatment and biomarker | [104] |
miR-21-5p | – | Affecting the apoptotic potential of stromal cells. | Treatment | [92] |
miR-9 | Down-regulated | Affecting BCL-2 expression | Treatment and biomarker | [83] |
miR181c | – | NR4A-miR181c-Mst1 pathway regulates mitochondrial apoptosis | Treatment | [105] |
miR-2861 | Down-regulated | Up-regulation of STAT3 and MMP2 and inducing apoptosis | Treatment and biomarker | [106] |
miR-141-3p | – | Down-regulation the expression of Bcl-2 and raising the expression of Bax and contributing to the apoptosis of ectopic ESCs | Treatment | [82] |