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Table 1 Summary of the ubiquitination and ubiquitination like systems

From: Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

ModificationModifier encoding geneMature modifier proteinE1E2E3Active protease
UbiquitinationUBB, UBC, UBA52 and RPS27A76 amino acids2 (UBA1 and UBA6)~ 40Over 600Dozens (USPs,UCHs,OTUs,MJD,JAMM)
SumoylationSUMO1-4varies from SUMO1-41 (SAE)1 (UBC9)A dozen6 (SENPs)
NeddylationNEDD876 amino acids1 (NAE)2 (UBC12 and UBE2F)Over 6003 (UCHL1, UCHL3 and USP21)
UfmylationUFM183 amino acids1 (UBA5)1 (UFC1)1 (UFL1)1 (UFSP2)
IsgylationISG15163 amino acids1 (UBE1L)1 (UBCH8)2 (HERC5 and TRIM25)5 (USP18, USP2, USP5, USP13 and USP14)
FatylationFAT10165 amino acids1 (UBA6)1 (USE1)UnknownUnknown