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Table 1 Major histone modification writers, erasers and readers

From: Control of mesenchymal stem cell biology by histone modifications

TypeMajor memberModification/identification siteFunction
Writers
 Histone acetylationGCN5H3K9, H3K14, H3K18, H3K36, H4K8Transcriptional activation
p300/CBPH2AK5
H3K18, H3K27
H4K8, H4K12
Transcriptional activation
Tip60H2AK5
H3K14
H4K5, H4K8, H4K12, H4K16
Transcriptional activation
 Histone methylationSUV39h1
SUV39h2
H3K9Transcriptional silencing
G9aH3K9Transcriptional repression
SETDB1H3K9Transcriptional repression
EZH2H3K27Transcriptional silencing
SETD2H3K36Transcriptional elongation
CARM1H3R17, H3R26, H3R42Transcriptional activation
 Histone phosphorylationAurora BH3S10, H3S28Transcriptional activation
 Histone ubiquitylationRing1BH2ATranscriptional repression
Rad6H2BTranscriptional elongation
Erasers
 Histone methylationLSD1H3K4, H3K9Transcriptional activation/repression
KDM4BH3K9Transcriptional activation
KDM6BH3K27Transcriptional activation
JMJD1CH3K9Transcriptional activation
 Histone acetylationHDAC1H2A, H2B, H3, H4Transcriptional repression
HDAC4H2A, H2B, H3, H4Transcriptional repression
HDAC6H2A, H2B, H3, H4Transcriptional repression
HDAC8H2A, H2B, H3, H4Transcriptional repression
 Histone phosphorylationPP1H3S10, H3S28Transcriptional repression
 Histone ubiquitylationUbp8H2BTranscriptional activation
Readers
 Acetyl-lysine binding domainsBRD2Acetylated lysineChromatin remodeling
 Methyl-lysine binding domainsBrpf1
HP1
L3MBTL1
Methylated lysine