From: Control of mesenchymal stem cell biology by histone modifications
Type | Major member | Modification/identification site | Function |
---|---|---|---|
Writers | |||
 Histone acetylation | GCN5 | H3K9, H3K14, H3K18, H3K36, H4K8 | Transcriptional activation |
p300/CBP | H2AK5 H3K18, H3K27 H4K8, H4K12 | Transcriptional activation | |
Tip60 | H2AK5 H3K14 H4K5, H4K8, H4K12, H4K16 | Transcriptional activation | |
 Histone methylation | SUV39h1 SUV39h2 | H3K9 | Transcriptional silencing |
G9a | H3K9 | Transcriptional repression | |
SETDB1 | H3K9 | Transcriptional repression | |
EZH2 | H3K27 | Transcriptional silencing | |
SETD2 | H3K36 | Transcriptional elongation | |
CARM1 | H3R17, H3R26, H3R42 | Transcriptional activation | |
 Histone phosphorylation | Aurora B | H3S10, H3S28 | Transcriptional activation |
 Histone ubiquitylation | Ring1B | H2A | Transcriptional repression |
Rad6 | H2B | Transcriptional elongation | |
Erasers | |||
 Histone methylation | LSD1 | H3K4, H3K9 | Transcriptional activation/repression |
KDM4B | H3K9 | Transcriptional activation | |
KDM6B | H3K27 | Transcriptional activation | |
JMJD1C | H3K9 | Transcriptional activation | |
 Histone acetylation | HDAC1 | H2A, H2B, H3, H4 | Transcriptional repression |
HDAC4 | H2A, H2B, H3, H4 | Transcriptional repression | |
HDAC6 | H2A, H2B, H3, H4 | Transcriptional repression | |
HDAC8 | H2A, H2B, H3, H4 | Transcriptional repression | |
 Histone phosphorylation | PP1 | H3S10, H3S28 | Transcriptional repression |
 Histone ubiquitylation | Ubp8 | H2B | Transcriptional activation |
Readers | |||
 Acetyl-lysine binding domains | BRD2 | Acetylated lysine | Chromatin remodeling |
 Methyl-lysine binding domains | Brpf1 HP1 L3MBTL1 | Methylated lysine |